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Journal of Ophthalmology
Volume 2017, Article ID 7656418, 9 pages
Clinical Study

Combination of Navigated Macular Laser Photocoagulation and Anti-VEGF Therapy: Precise Treatment for Macular Edema under Dry Retinal Conditions

1St. Petersburg Branch of the Academician S. Fyodorov IRTC “Eye Microsurgery”, 21 Yaroslav Gashek St., Saint Petersburg 192283, Russia
2Department of Ophthalmology, Mechnikov North-West State Medical University, 47 Kirochnaya St., Saint Petersburg 191015, Russia
3Department of Ophthalmology, Military Medical Academy, 5 Klinicheskaya St., Saint Petersburg 194044, Russia

Correspondence should be addressed to Dmitrii S. Maltsev; ur.xednay@dem.zalg

Received 2 August 2016; Revised 14 November 2016; Accepted 4 January 2017; Published 20 February 2017

Academic Editor: Raffael Liegl

Copyright © 2017 Ernest V. Boiko and Dmitrii S. Maltsev. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Purpose. To compare the controllability of navigated macular laser photocoagulation (MLP) in dry versus edematous retina and validate that pretreatment diagnostic images can be used as basis for navigated MLP after the macular edema (ME) has been resolved. Materials and Methods. Group 1 was divided into subgroup 1 (dry retina MLP) and subgroup 2 (MLP in ME) for comparisons of laser-burn diameters. In group 2, the areas and locations of ME before an intravitreal injection of anti-VEGF (IVAV) were compared with those of recurrent ME. Results. The average actual diameter as percentage of planned diameter of laser burn in subgroup 1 (11 DME eyes, 6 BRVO eyes) versus subgroup 2 (5 DME eyes, 8 BRVO eyes) was 115.1 ± 9.1% versus 167.2 ± 13.8% (based on retro-mode scanning laser ophthalmoscopy), and 118.1 ± 14.8% versus 176.1 ± 11.6% (based on OCT) (). In group 2 (6 DME eyes, 6 BRVO eyes), difference in mean ME area before IVAV and that in recurrent edema was insignificant (). Conclusion. The controllability of navigated MLP in dry retina is improved compared to edematous retina. This study validates that pretreatment diagnostic images can be used as basis for navigated MLP after the edema has been resolved.