Glaucomatous Optic Nerve Changes and Thyroid Dysfunction in an Urban South Korean Population
Table 5
Adjusted coefficients and 95% confidence intervals of IOP stratified by each thyroid function parameter in a normal population without glaucoma.
Variables
Coefficients
95% confidence interval
value
Age
0.025
(0.024–0.027)
<0.001
Sex (male)
0.726
(0.693–0.759)
<0.001
Diabetes
0.697
(0.609–0.784)
<0.001
Hypertension
0.381
(0.326–0.436)
<0.001
Hyperlipidaemia
0.150
(0.106–0.194)
<0.001
Current smoker
0.234
(0.194–0.275)
<0.001
TSH (μIU/mL)
1st quartile (<1.30)
0 (reference)
2nd quartile (1.30–1.90)
0.074
(0.033–0.115)
<0.001
3rd quartile (1.90–2.75)
0.135
(0.094–0.177)
<0.001
4th quartile (≥2.75)
0.159
(0.117–0.200)
<0.001
Age
0.025
(0.023–0.026)
<0.001
Sex (male)
0.766
(0.732–0.801)
<0.001
Diabetes
0.702
(0.614–0.789)
<0.001
Hypertension
0.384
(0.329–0.439)
<0.001
Hyperlipidaemia
0.146
(0.102–0.190)
<0.001
Current smoker
0.220
(0.180–0.259)
<0.001
Free T4 (ng/dL)
1st quartile (<1.15)
0 (reference)
2nd quartile (1.15–1.26)
−0.025
(−0.066–0.016)
0.239
3rd quartile (1.26–1.38)
−0.087
(−0.129 to −0.044)
<0.001
4th quartile (≥1.38)
−0.176
(−0.221 to −0.131)
<0.001
Age
0.025
(0.023–0.027)
<0.001
Sex (male)
0.737
(0.702–0.773)
<0.001
Diabetes
0.693
(0.606–0.781)
<0.001
Hypertension
0.381
(0.326–0.436)
<0.001
Hyperlipidaemia
0.152
(0.108–0.196)
<0.001
Current smoker
0.216
(0.176–0.256)
<0.001
T3 (pg/mL)
1st quartile (<2.87)
0 (reference)
2nd quartile (2.87–3.12)
−0.102
(−0.143 to −0.060)
<0.001
3rd quartile (3.12–3.40)
−0.043
(−0.085 to −0.001)
0.045
4th quartile (≥1.38)
−0.050
(−0.094 to −0.006)
0.027
Hypothyroidism
−0.091
(−0.200–0.017)
0.099
Hyperthyroidism
0.042
(−0.071–0.156)
0.465
Nodular cyst
0.071
(0.011–0.130)
0.019
Hormone treatment
−0.004
(−0.113–0.104)
0.938
Adjusted for age, sex, diabetes, hypertension, hyperlipidaemia, and current smoker. Diabetes is diagnosed as previous diagnosis or treatment history of diabetes or fasting plasma glucose (126 mg/dL). Hypertension is diagnosed as a systolic blood , a diastolic blood , or current use of antihypertensive drugs. Hyperlipidaemia is diagnosed as abnormally elevated serum level of any or all lipids and/or lipoproteins. Multivariate linear regression analysis.
