Journal of Ophthalmology / 2017 / Article / Tab 5

Research Article

Glaucomatous Optic Nerve Changes and Thyroid Dysfunction in an Urban South Korean Population

Table 5

Adjusted coefficients and 95% confidence intervals of IOP stratified by each thyroid function parameter in a normal population without glaucoma.

VariablesCoefficients95% confidence interval value

Age0.025(0.024–0.027)<0.001
Sex (male)0.726(0.693–0.759)<0.001
Diabetes0.697(0.609–0.784)<0.001
Hypertension0.381(0.326–0.436)<0.001
Hyperlipidaemia0.150(0.106–0.194)<0.001
Current smoker0.234(0.194–0.275)<0.001
TSH (μIU/mL)
 1st quartile (<1.30)0 (reference)
 2nd quartile (1.30–1.90)0.074(0.033–0.115)<0.001
 3rd quartile (1.90–2.75)0.135(0.094–0.177)<0.001
 4th quartile (≥2.75)0.159(0.117–0.200)<0.001

Age0.025(0.023–0.026)<0.001
Sex (male)0.766(0.732–0.801)<0.001
Diabetes0.702(0.614–0.789)<0.001
Hypertension0.384(0.329–0.439)<0.001
Hyperlipidaemia0.146(0.102–0.190)<0.001
Current smoker0.220(0.180–0.259)<0.001
Free T4 (ng/dL)
 1st quartile (<1.15)0 (reference)
 2nd quartile (1.15–1.26)−0.025(−0.066–0.016)0.239
 3rd quartile (1.26–1.38)−0.087(−0.129 to −0.044)<0.001
 4th quartile (≥1.38)−0.176(−0.221 to −0.131)<0.001

Age0.025(0.023–0.027)<0.001
Sex (male)0.737(0.702–0.773)<0.001
Diabetes0.693(0.606–0.781)<0.001
Hypertension0.381(0.326–0.436)<0.001
Hyperlipidaemia0.152(0.108–0.196)<0.001
Current smoker0.216(0.176–0.256)<0.001
T3 (pg/mL)
 1st quartile (<2.87)0 (reference)
 2nd quartile (2.87–3.12)−0.102(−0.143 to −0.060)<0.001
 3rd quartile (3.12–3.40)−0.043(−0.085 to −0.001)0.045
 4th quartile (≥1.38)−0.050(−0.094 to −0.006)0.027

Hypothyroidism−0.091(−0.200–0.017)0.099
Hyperthyroidism0.042(−0.071–0.156)0.465
Nodular cyst0.071(0.011–0.130)0.019
Hormone treatment−0.004(−0.113–0.104)0.938

Adjusted for age, sex, diabetes, hypertension, hyperlipidaemia, and current smoker.
Diabetes is diagnosed as previous diagnosis or treatment history of diabetes or fasting plasma glucose (126 mg/dL).
Hypertension is diagnosed as a systolic blood , a diastolic blood , or current use of antihypertensive drugs.
Hyperlipidaemia is diagnosed as abnormally elevated serum level of any or all lipids and/or lipoproteins.
Multivariate linear regression analysis.

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