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Journal of Ophthalmology
Volume 2017, Article ID 8532397, 6 pages
Research Article

Analysis of Clinical Characteristics of Immune-Related Dry Eye

1Ophthalmology Department, Xiangya Hospital, Central South University, Changsha, Hunan Province 410008, China
2Hunan Provincial People’s Hospital, Changsha, Hunan Province 410016, China

Correspondence should be addressed to Qiang-Xiang Li; moc.361@ilgnaixgnaiq

Received 16 January 2017; Accepted 12 April 2017; Published 30 May 2017

Academic Editor: Stephen Charn Beng Teoh

Copyright © 2017 Hua Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Aim. To discuss the clinical characteristics of immune-related dry eye. Methods. Simple dry eye (SDE) group: we selected 224 patients of simple dry eye with no systemic lesions. Immune-related dry eye (IRDE) group: we selected 207 patients of dry eye complicated with immune system diseases, including 70 cases of Sjögren’s syndrome (SS), 72 cases of systemic lupus erythematosus (SLE), and 65 cases of rheumatoid arthritis (RA). The classification of all patients was performed. The difference between the two groups was compared, including age, gender, ocular surface fluorescein staining and inflammatory reaction, tear breakup time (TBUT), Shirmer I test, confocal microscopy scan, and dry eye grading. Results. Compared with the SDE group, the patients of IRDE group were younger (). The female patients were significantly more than the male ones (). Corneal staining counts and ocular surface inflammation were significantly increased (). TBUT and Shirmer I test shortened significantly (). Corneal nerve fibers were less, and the number of local lymphocyte was significant increased. The number of dry eye patients in the moderate or above IRDE group was significantly increased (). Conclusions. The dry eye symptom and sign and ocular surface inflammation of IRDE were significantly more severe than those of the SDE.