Antiendothelial proliferation in vitro [44, 45]; antiendothelial migration in vitro [44, 45]; antiangiogenesis in vivo retina [43, 45]; antiangiogenesis in vivo choroid [63, 66]
Possible induction of membrane contraction and tractional retinal detachment [23]; vessel contraction [25]
Inhibition of membrane contraction in vivo [50, 73]; reduced collagen synthesis in RPE [66]; inhibition of gel contraction by RPE [72, 73]; anti-RPE proliferation [72]; actin depolymerization in RPE [74]
Neuronal damage
Possible induction of photoreceptor damage [85, 86]