Rho-Kinase/ROCK as a Potential Drug Target for Vitreoretinal Diseases

Table 2

ROCK inhibitors in animal models of vitreoretinal diseases.

Animal model	OIR model; (oxygen-induced retinopathy)	STZ model; (streptozotocin-induced; diabetes model)	CNV model (choroidal; neovascularization model)	PVR (proliferative; vitreoretinopathy model)
Fasudil	Antiangiogenesis [45]	Antileukostasis [38]	Antipermeability [63]; anti-M2 macrophage [63]; antiangiogenesis [63]	Inhibition of membrane; contraction [50]
Ripasudil (K115)	Vascular normalization; via pericyte coverage [45]; antiangiogenesis [45]	No report	No report	No report
Y27632	Antiangiogenesis [43]	No report	No report	Inhibition of membrane; contraction [73]
AMA0428	Antiangiogenesis [89]; inhibition neuronal cell; death [89]	Antileukostasis [89]; antipermeability [89]; neuroprotection of RGC [89]	Antiangiogenesis [66]; antifibrosis [66]; antiinflamation [66]	No report