|
| Author | Type of study | Sample size (eyes) | Severity KC | Follow-up (months) (mean) | Age (years) (mean ± SD) | Sex (male/female) | UCVA (logMAR) | BCLCVA (logMAR) | Comfort level | Other findings |
|
| Zadnik et al. [98] | Cross-sectional, observational | 2418 | Mild (110 eyes), moderate (1172 eyes), severe (1130 eyes) | NR | 39.3 ± 10.9 | 55.9%/44.1% | Entrance VA.
(Patients)
0.0 or better: 409
>0.0 to 0.3: 693
>0.3 to 0.54: 84
>0.54 to 1.0: 18
>1.0: 18 | (Patients)
0.0 or better: 538
>0.0 to 0.3: 612
>0.3 to 0.54: 43
>0.54 to 1.0: 10
>1.0: 1 | 72.8% comfortable
27.1% irritating at least one eye | SCL: 4%
RGPCL: 73%
Piggyback: 2%
Hybrid: 3%
Eye rubbing: 50.4%
Vogt’s striae: 65%
Fleischer’s ring: 86%
Corneal scarring: 53%
Corneal irregularity: 99.7% |
| Bilgin et al. [41] | Retrospective, cohort | 1004 | Mild (5 (47%))
Moderate (4 (5%))
Severe (40.1%) | 18–30 | 34.8 ± 10.1 | 52.7%/47.3% | 0.62 mild
0.70 moderate
1.30 severe | 0.10 mild
0.10 moderate
0.22 severe | New adaptation due to intolerance and irritation:
32.7% mild KC
23.7% moderate KC
17.6% severe KC | PKP: 2.0%
Acute hydrops: 0.3%
Unilateral KC: 10.6%
Cone like shape: 20.6%
Subepithelial opacity: 14%
Descemet folds: 8.6%
Fleischer’s ring: 1.8%
Munson’s sign: 6.2%
Vogt’s striae: 7.5% |
| Hwang et al. [35] | Prospective, case–control | 107 | Mild (3.7%)
Moderate (43.9%)
Severe (52.3%) | 22.6 | 25.4 ± 6.8 cases
22.3 ± 7.7 controls | 53.3%/46.7% | Spectacle corrected
0.68 cases
0.54 controls | −0.032 cases | 87% comfortable
9.1% slightly uncomfortable
3.9% uncomfortable | |
| Kamar et al. [33] | Prospective, cohort | 30 | Mild (4 eyes)
Moderate (14 eyes)
Severe (12 eyes) | 22 | 48.5 ± 9.9 | 50%/50% | Contact lens corrected
0.20 | Pancorneal RGPCL
0.15 | 6.6% intolerance | Improvement in corneal compression: 77% |
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