Nonsurgical Procedures for Keratoconus Management

Table 5

Description of the main studies in keratoconus (KC) management with hybrid contact lens (HCL) system.

Author	Type of study	Type of CL	Sample size (eyes)	Severity KC	BCLCVA (logMAR) (mean)	Follow-up (months) (mean)	Mean age or age (years)	Sex (female/male)
Ozkurt et al. [108]	Retrospective case series	SoftPerm CL	24	NR	Better than +0.5	23	25.78	8/6
Nau [107]	Retrospective	SynergEyes HCLs versus RPGCLs	79	NR	+0.2	3	36.17	32/21
Abdalla et al. [112]	Retrospective	SynergEyes HCLs	61	Moderate and severe	0.0 To +0.1 (31.1%); +0.2 to +0.3 (62.3%)	7.8	40	18/26
Carracedo et al. [113]	Prospective comparative	ClearKone HCLs versus patient habitual CL	33	Moderate and severe	−0.024	1	26.3	5/13
Hahemi et al. [106]	Comparative case series	ClearKone HCLs (group 1) versus RPGCLs (group 2)	40	Moderate	Group 1 : 0.01; Group 2 : 0.02	2	Group 1: 33.71; Group 2: 32.16	21/19

BCLCVA: best contact lens corrected visual acuity; NR: not reported; OD: right eye; CL: contact lens. Mild KC (average sim K < 45 D). Moderate (average sim K 45–52 D). Severe (average sim K > 52 D).