The Involvement of β-Catenin/COX-2/VEGF Axis in NMDA-Caused Retinopathy

Figure 3

NS-398 could attenuate the NMDA-induced activation of β-catenin causing neuron cell loss. (a) Representative images (H&E staining, expression of β-catenin, COX-2, and VEGF) of the rats. (b) Neuron number of RGCs with respect to control (untreated), in NMDA-injected retinas of animals treated with NS-398. (c) β-Catenin expression of retinas with respect to control in NMDA-injected retinas of animals treated with NS-398. (d) COX-2 expression of retinas with respect to control in NMDA-injected retinas of animals treated with NS-398. (e) VEGF expression of retinas with respect to control in NMDA-injected retinas of animals treated with NS-398.

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