Association between Visual Acuity and Retinal Layer Metrics in Diabetics with and without Macular Edema

Table 3

Multivariate associations of retinal layer thickness and reflectance ratio with logMAR visual acuity based on data from subjects without DME (N = 121).

Metrics	Thickness (microns), mean ± SD	Regression coefficient (95% CI) [1]
NFLT	18 ± l3	0.004 (−0.060, 0.068)
GCLIPLT	28 ± 12	−0.003 (−0.021, 0.016)
INLT	21 ± 8	0.048 (0.023, 0.073)
OPLT	21 ± 8	0.029 (0.001, 0.056)
ONLT	114 ± 22	−0.002 (−0.012, 0.007)
OSLT	44 ± 7	−0.008 (−0.036, 0.019)
Metrics	Reflectance ratio, mean ± SD	Regression coefficient (95% CI) [1]
NFLR	0.54 ± 0.07	0.029 (0, 0.057)
GCLIPLR	0.61 ± 0.07	0.021 (−0.010, 0.052)
INLR	0.50 ± 0.06	0.010 (−0.025, 0.044)
OPLR	0.52 ± 0.06	0.009 (−0.026, 0.045)
ONLR	0.37 ± 0.05	0.043 (0.001, 0.085)
OSLR	0.81 ± 0.07	−0.007 (−0.037, 0.023)

. ¹Regression coefficients represent logMAR change with 10 micron increase in thickness or 0.1 increase in reflectance ratio, after adjusting for age, sex, race, diabetes type, diabetes duration, and HbA1c. NFL = nerve fiber layer; GCLIPL = ganglion cell layer + inner plexiform layer; INL = inner nuclear layer; OPL = outer plexiform layer; ONL = outer nuclear layer; OSL = photoreceptor outer segment layer; RPE = retinal pigment epithelium. Suffix T = thickness; suffix R = reflectance ratio.