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Journal of Ophthalmology
Volume 2018, Article ID 1345409, 12 pages
Research Article

Mapping the Structure-Function Relationship in Glaucoma and Healthy Patients Measured with Spectralis OCT and Humphrey Perimetry

1Ophthalmology Service, University Hospital Ramón y Cajal, School of Medicine and Health Science, University of Alcalá, IRYCIS, Hospital Ramón y Cajal, Ctra. Colmenar Viejo km. 9100, 28034 Madrid, Spain
2Ophthalmology Service, University Hospital Ramón y Cajal, IRYCIS, Hospital Ramón y Cajal, Ctra. Colmenar Viejo km. 9100, 28034 Madrid, Spain

Correspondence should be addressed to Laia Jaumandreu; moc.nsm@uerdnamuajaial

Received 3 November 2017; Revised 15 February 2018; Accepted 1 March 2018; Published 17 April 2018

Academic Editor: Paolo Fogagnolo

Copyright © 2018 Laia Jaumandreu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Purpose. To study the structure-function relationship in glaucoma and healthy patients assessed with Spectralis OCT and Humphrey perimetry using new statistical approaches. Materials and Methods. Eighty-five eyes were prospectively selected and divided into 2 groups: glaucoma (44) and healthy patients (41). Three different statistical approaches were carried out: (1) factor analysis of the threshold sensitivities (dB) (automated perimetry) and the macular thickness (μm) (Spectralis OCT), subsequently applying Pearson’s correlation to the obtained regions, (2) nonparametric regression analysis relating the values in each pair of regions that showed significant correlation, and (3) nonparametric spatial regressions using three models designed for the purpose of this study. Results. In the glaucoma group, a map that relates structural and functional damage was drawn. The strongest correlation with visual fields was observed in the peripheral nasal region of both superior and inferior hemigrids ( and , resp.). The estimated functions obtained with the nonparametric regressions provided the mean sensitivity that corresponds to each given macular thickness. These functions allowed for accurate characterization of the structure-function relationship. Conclusions. Both maps and point-to-point functions obtained linking structure and function damage contribute to a better understanding of this relationship and may help in the future to improve glaucoma diagnosis.