Risk Factors for Endothelial Decompensation after Penetrating Keratoplasty and Its Novel Therapeutic Strategies

Table 1

Studies on 10-year graft survival of PKP.

Study	Sample size	10-year survival rate (%)	Indication (N)	Follow-up time
Lass et al. [3]	1090	74.5	Fuchs dystrophy (676)	10 years
			Pseudophakic or aphakic
			Corneal edema (PACE) (369)
Williams et al. [4]	16291	89	Keratoconus (6249)	<1 year (24%)
		37	Bullous keratopathy (4338)	1–6 years (58%)
		36	Failed previous graft (4227)	6–12 years (14%)
		66	Corneal dystrophy (2156)	12–18 years (4%)
				>18 years (1%)
Kelly et al. [5]	4834	89	Keratoconus (4834)	23 years
Anshu et al. [6]	901	90.7	Keratoconus (87)	36.8 ± 35.5 months.
		20.0	Fuchs’ endothelial dystrophy (64)
		33.5	Pseudophakic/aphakic bullous keratopathy (211)
		—	Regraft (112)
Sugar et al. [7]	1090	80	Fuchs dystrophy (676)	12 years
		63	Pseudophakic or aphakic corneal edema (PACE) (369)
Patel et al. [8]	388	80	Fuchs dystrophy (108)	20 years
			Keratoconus (83)
			Pseudophakic corneal edema (73)
			Aphakic corneal edema (68)
Borderie et al. [9]	1144	64.4	Keratoconus (258)	40.5 ± 32.1 months
			Bullous keratopathy (449)
			Endothelial dystrophies (121)
			Regraft (87)
Williams et al. [10]	10952	62	Keratoconus	Up to 15 years (mean follow-up time is not available)
			Regraft
			Dystrophy
			Aphakic bullous keratopathy
			Pseudophakic bullous keratopathy (ratios are not available)
Inoue et al. [11]	271	79.3	Keratoconus (64)	46.5 ± 35.1 months
			Bullous keratopathy (55)
			Nonherpetic keratitis (49)
			Graft failure (39)
			Herpes keratitis (38)
			Corneal dystrophies and degenerations (20)
			Chemical burns (6)
Thompson et al. [12]	3992	82	Primary grafts (3640)	43 ± 34 months
		92	Keratoconus (449)
		90	Fuchs’ dystrophy (908)
		41	Regraft (352)
Inoue et al. [13]	396	72.2	Overall (396)	46.6 ± 30.4 months
		98.8	Keratoconus (82)
		76.9	Corneal dystrophy (26)
		61.8	Regraft (68)
		51.1	Bullous keratopathy (94)

Data from the same group and same research population (Cornea Donor Study).