|
| Study | Sample size (the number of eyes) | Baseline mean ECD (95% confidence interval) | ECD (95% confidence interval) | ECD loss (%) | Precision of measurements | Follow-up time |
| 5 years | 10 years |
|
| Lass et al. [3] | 1090 | 2661 (95% confidence interval not available) | — | 614 (95% confidence interval not available) | 77% from baseline to 5 years | Using a specular microscope | 10 years |
| Kettesy et al. [23] | 68 | — | 1501 (1442, 1560) (at examination time) | 15.8% per year in first 2 years | Using a contact specular microscope | 67.8 ± 74.1 months (range: 12–276 months) |
| Abbott et al. [26] | 100 | — | 684 (at examination time) | — | With specular microscopy | Average follow-up of 17.4 years (range 10–36 years) |
| Linn et al. [27] | 55 | — | 941(832, 1050) (at examination time) | 50 % per 10 years | Using Zeiss noncontact endothelial lens | 2.5 years to 35 years |
| Minimum 41 of cells were counted |
| Lass et al. [28] | 567 | 2698 (95% confidence interval not available) | 778 (95% confidence interval not available) | — | 70% from baseline to 5 years | Using a specular microscope | 5 years |
| Patel et al. [8] | 393 | 2973 (2919, 3027) | 1191 (1116, 1266) | 960 (876, 1044) | 67 ± 17 (%) from baseline to 10 years | Using a specular microscope | 20 years |
| Bourne et al. [29] |
| Patel et al. [15] | The outlines or apices of at least 50 endothelial cells were digitized |
| Ing et al. [24] |
| Borderie et al. [9] | 1144 | 2264 (2247, 2281) | 1058 (95% confidence interval not available) | 865 (95% confidence interval not available) | 41 ± 24% over the first 2 years, followed by a 10 ± 6% yearly decrease afterward | Using wide-field specular microscopy | 40.5 ± 32.1 months |
| Inoue et al. [30] | 15 | — | — | 998 (824, 1172) | 12.1 ± 16.3% from 10 years to 20 years | Using nonapplanation contact specular microscopy | 24.8 ± 3.1 years |
| A minimum of 50 cells was counted in each photograph |
| Lass et al. [31] | 176 | 2695 (2498, 2890) | 786 (616, 1343) | 611 (502, 769) | 76% | Using specular or confocal microscope | 10 years |
| 95% confidence interval (70%, 82%) | With masked image quality grading and ECD determination |
| From baseline to 10 years | Minimum 15 of cells of each variable frame |
|
