Functional and Structural Outcomes of Temporal Zone II-Sparing Laser Photocoagulation Combined with Intravitreal Bevacizumab in Retinopathy of Prematurity

Table 1

Baseline characteristics of the subjects.

	Temporal-sparing LIO + IVB	LIO alone	value
Number of infants (eyes)	16 (32)	21 (42)
Gestational age at birth (weeks)	25.1 ± 1.3	26.2 ± 3.0	0.169^‡
Birth weight (g)	673.1 ± 145.8	594.5 ± 557.3	0.132^‡
Follow-up period (weeks)	84.4 ± 36.9	117.4 ± 43.6	0.020^‡
Eyes with aggressive posterior ROP (%)	10 (31.3)	0 (0)	<0.001
Multiplicity (%)			0.502
Single	9 (56.3)	12 (57.1)
Twins	6 (37.5)	9 (42.9)
Triplets	1 (6.2)	0 (0.0)
APGAR score
1 minute	3.1 ± 2.2	4.0 ± 1.6	0.186^‡
5 minutes	5.2 ± 2.7	6.1 ± 1.1	0.155^‡
Ventilator care period (days)	75.6 ± 29.0	67.1 ± 35.0	0.427^‡
O2 therapy period (days)	96.9 ± 30.3	88.4 ± 42.9	0.485^‡
Comorbid conditions
NEC operation (%)	5 (31.3)	2 (9.5)	0.095
PDA ligation (%)	12 (75.0)	20 (95.2)	0.144^†
RDS (%)	15 (93.8)	21 (100)	0.432^†
BPD ≥ moderate (%)	5 (31.3)	12 (57.1)	0.117^†
Sepsis (%)	11 (68.8)	12 (57.1)	0.471
IUGR (%)	2 (12.5)	7 (33.3)	0.248^†
Poor weight gain (%)	15 (93.8)	16 (76.2)	0.206^†
Hydrocephalus (%)	2 (12.5)	7 (33.3)	0.248^†
IVH (%)			0.448
None	4	2
Grade I-II	9	14
Grade III-IV	3	5

Continuous variables are shown as mean ± SD; chi-square analysis; ^†Fisher’s exact test; ^‡Student’s t-test; NEC, necrotising enterocolitis; PDA, patent ductus arteriosus; RDS, respiratory distress syndrome; BPD, bronchopulmonary dysplasia; IUGR, intrauterine growth restriction; IVH, intraventricular haemorrhage.