Flt3 Regulation in the Mononuclear Phagocyte System Promotes Ocular Neovascularization

Figure 5

Inhibition of Flt3 reduces VEGF-induced subretinal NV. Immunofluorescence staining of retinal flat mounts from rho/VEGF animals after treatment with PBS and AC220. AC220 was intravitreally administered in one eye and PBS in the contralateral eye of rho/VEGF mice at P12, and retinas were obtained, stained, and flat mounted at P21 (). The total number and area of subretinal NV decreased significantly in AC220-treated eyes compared with those in the PBS group (a–c).

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