Nanophthalmos: A Review of the Clinical Spectrum and Genetics

Table 2

Clinical spectrum of eye size phenotypes based on axial length [5] and anterior segment features by anterior chamber depth and white-to-white corneal diameter [6–8].

	Axial length
		Short (<21 mm)	Average (24 mm)	Long (>27 mm)
Anterior segment	Small (WTW < 11 mm; ACD < 3.0 mm)	Microphthalmos and nanophthalmos	Relative anterior microphthalmos	Complex dysgenesis
	Average (WTW∼11–12.5 mm; ACD∼3.3 mm)	Hyperopia posterior microphthalmos	Normal	Myopia
	Large (WTW > 12.5 mm ACD > 3.3 mm)	Complex dysgenesis	Megalocornea	Infantile or congenital glaucoma myopia