Table 3: Multivariate logistic regression analyses for the association between open-angle glaucoma and age at menarche, early menopause, and parity.

AllNatural menopause
OR (95% CI) valueOR (95% CI) value

Age at menarche, years
 13–16 yearsModel IReference0.506Reference0.397
 ≤12 years0.99 (0.45–2.15)1.10 (0.40–3.02)
 ≥17 years0.83 (0.60–1.14)0.79 (0.56–1.13)
 13–16 yearsModel IIReference0.425Reference0.279
 ≤12 years1.01 (0.38–2.65)1.10 (0.39–3.15)
 ≥17 years0.80 (0.56–1.13)0.75 (0.52–1.09)

Early menopause <45 years
Model I1.50 (0.96–2.34)0.0732.05 (1.22–3.50)0.009
Model II1.60 (0.94–2.73)0.0822.28 (1.17–4.46)0.016

Parity
Model I1.03 (0.97–1.09)0.4151.02 (0.96–1.08)0.556
Model II1.02 (0.95–1.10)0.6311.02 (0.94–1.11)0.686

CI = confidence interval. Model I, adjusted for age, diabetes mellitus, hypertension, myopia, body mass index, oral contraceptive use, and hormone replacement. Model II, adjusted for age, diabetes mellitus, hypertension, myopia, body mass index, oral contraceptive use, hormone replacement, and female reproductive factors (age at menarche, early menopause, lactation history, and parity).