Treatment of Diabetic Macular Edema with Intravitreal Antivascular Endothelial Growth Factor and Prompt versus Deferred Focal Laser during Long-Term Follow-Up and Identification of Prognostic Retinal Markers

Figure 2

Spectral domain optical coherence tomography (SD-OCT) images of the left eye of 2 patients treated with ranibizumab and prompt focal laser therapy (A–F) or ranibizumab in addition to deferred laser (H–L) at baseline (B, H), 6 months (C, I), 1 year (D, J), 2 years (E, K), and 5 years (F, L) following baseline. SD-OCT images indicate a more rapid and consistent decrease of central retinal thickness (CRT) values in the eye treated with prompt laser therapy compared with the eye randomized for deferred focal laser treatment. In this example, the decrease in CRT is particularly evident in the eye that received prompt laser therapy in the beginning of the treatment phase (until month 6) compared with the eye that was scheduled for the deferred group. Note that the baseline CRT was similar in both eyes of the different treatment arms. The arrow indicates clusters of hyperreflective intraretinal material.