Treatment of Diabetic Macular Edema with Intravitreal Antivascular Endothelial Growth Factor and Prompt versus Deferred Focal Laser during Long-Term Follow-Up and Identification of Prognostic Retinal Markers
Table 2
Functional ((best-corrected visual acuity (BCVA)) and morphological (central retinal thickness (CRT)) results in eyes with diabetic macular edema (DME, 50 eyes, top) treated with intravitreal ranibizumab and immediate focal laser therapy (prompt group, 25 eyes, middle) and eyes treated with intravitreal ranibizumab and deferred laser (25 eyes, bottom).
Baseline
6 weeks
12 weeks
18 weeks
6 months
9 months
1 year
2 years
3 years
4 years
5 years
Entire study population
BCVA
0.32
0,50
0.50
0.50
0.50
0.50
0.50
0.72
0.67
0.62
0.68
SD
0.03
0,03
0.03
0.04
0.04
0.03
0.03
0.42
0.26
0.26
0.25
logMAR (Snellen)
0.50 (20/40)
0.30 (20/63)
0.30 (20/63)
0.30 (20/63)
0.30 (20/63)
0.30 (20/63)
0.30 (20/63)
0.20 (20/100)
0.25 (20/80)
0.30 (20/63)
0.20 (20/100)
CRT
457.20
401.6
391.3
381.10
269.60
358.90
351.90
377.40
363.00
343.80
348.30
SD
90.70
98.40
94.20
99.30
85.70
88.30
93.00
108.20
95.20
78.70
62.00
Prompt treatment group
BCVA
0.32
0.50
0.50
0.40
0.04
0.50
0.50
0.70
0.63
0.58
0.58
SD
0.03
0.04
0.04
0.05
0.04
0.03
0.03
0.39
0.36
0.29
0.31
logMAR (Snellen)
0.50 (20/40)
0.30 (20/63)
0.30 (20/63)
0.40 (20/50)
0.40 (20/50)
0.30 (20/63)
0.30 (20/63)
0.20 (20/100)
0.20 (20/100)
0.30 (20/63)
0.30 (20/63)
CRT
460.30
381.60
399.40
370.20
360.70
362.80
354.70
360.70
360.70
357.00
354.40
SD
87.40
70.20
91.50
113.50
101.50
106.10
94.10
105.80
106.90
108.00
108.90
Deferred treatment group
BCVA
0.32
0.50
0.40
0.40
0.40
0.40
0.50
0.61
0.56
0.53
0.61
SD
0.03
0.03
0.04
0.05
0.04
0.04
0.03
0.35
0.30
0.29
0.31
logMAR (Snellen)
0.50 (20/40)
0.30 (20/63)
0.40 (20/50)
0.40 (20/50)
0.40 (20/50)
0.40 (20/50)
0.30 (20/63)
0.30 (20/63)
0.30 (20/63)
0.30 (20/63)
0.30 (20/63)
CRT
454.10
389.70
382.00
370.20
360.70
348.80
340.90
363.40
352.40
342.10
327.60
SD
95.60
114.80
110.10
113.50
101.50
106.10
114.80
111.10
107.30
104.50
69.70
Note. BCVA = best-corrected visual acuity, SD = standard deviation, and CRT = central retinal thickness.
