Journal of Ophthalmology

Research Article

Treatment of Diabetic Macular Edema with Intravitreal Antivascular Endothelial Growth Factor and Prompt versus Deferred Focal Laser during Long-Term Follow-Up and Identification of Prognostic Retinal Markers

Table 3

Functional (best-corrected visual acuity (BCVA)) and morphological (central retinal thickness (CRT)) results in eyes with diabetic macular edema (DME) following treatment with intravitreal ranibizumab and focal laser therapy that reveal clusters of hyperreflective foci in the central macular area (27 eyes, 54%) and eyes without hyperreflective intraretinal foci (23 eyes, 46%). Results show that BCVA in eyes revealing clusters of hyperreflective foci in the central macular region detected by spectral domain optical coherence tomography (SD-OCT) was significantly inferior compared with eyes without clusters of hyperreflective intraretinal foci at year 5 (0.39 Snellen (SD = 0.25, 0.4 logMAR) versus 0.63 Snellen (SD = 0.22, 0.2 logMAR), )


	Baseline	6 weeks	12 weeks	18 weeks	6 months	9 months	1 year	2 years	3 years	4 years	5 years

Eyes revealing clusters of hyperreflective foci in the central macular area in SD-OCT
BCVA	0.32	0.50	0.50	0.50	0.50	0.50	0.50	0.72	0.67	0.62	0.68
SD	0.03	0.03	0.03	0.04	0.04	0.03	0.03	0.42	0.26	0.26	0.25
logMAR (Snellen)	0.50 (20/40)	0.30 (20/63)	0.30 (20/63)	0.30 (20/63)	0.30 (20/63)	0.30 (20/63)	0.30 (20/63)	0.20 (20/100)	0.20 (20/100)	0.20 (20/100)	0.20 (20/100)
CRT	457.20	401.60	391.30	381.10	269.60	358.90	351.90	377.40	363.00	343.80	348.30
SD	90.70	98.40	94.20	99.30	85.70	88.30	93.00	108.20	95.20	78.70	62.00
Eyes without clusters of hyperreflective foci in the central macular area in SD-OCT
BCVA	0.32	0.50	0.50	0.40	0.40	0.50	0.50	0.70	0.63	0.58	0.58
SD	0.03	0.04	0.04	0.05	0.04	0.03	0.03	0.39	0.36	0.29	0.31
logMAR (Snellen)	0.50 (20/40)	0.30 (20/63)	0.30 (20/63)	0.40 (20/50)	0.40 (20/50)	0.30 (20/63)	0.30 (20/63)	0.20 (20/100)	0.20 (20/100)	0.30 (20/63)	0.30 (20/63)
CRT	460.30	381.60	399.40	370.20	360.70	362.80	354.70	360.70	360.70	357.00	354.40
SD	87.40	70.20	91.50	113.50	101.50	106.10	94.10	105.80	106.90	108.00	108.90

Note. BCVA = best-corrected visual acuity, SD = standard deviation, and CRT = central retinal thickness.