The Role of Dll4/Notch Signaling in Normal and Pathological Ocular Angiogenesis: Dll4 Controls Blood Vessel Sprouting and Vessel Remodeling in Normal and Pathological Conditions

Figure 4

Retinal vascular development in normal (WT) (a) and Dll4-deficient heterozygous mice (Dll4^+/−) (b) at P6. Heterozygous Dll4 deletion causes severe developmental retinal vascular abnormalities leading to the increased blood vessel sprouting and formation of a syncytium-like vascular plexus (yellow arrowheads). 4x magnification. GS lectin staining. [33].

(a)

(b)