The Role of Dll4/Notch Signaling in Normal and Pathological Ocular Angiogenesis: Dll4 Controls Blood Vessel Sprouting and Vessel Remodeling in Normal and Pathological Conditions

Figure 7

Pharmacological inhibition of Dll4 in acute hyperoxia (6 hours, 75% O2) using soluble Dll4-Fc fusion protein (b) ameliorates pathological retinal capillary nonperfusion compared to Fc control (a). GS lectin-positive and tomato lectin-negative capillaries are transiently nonperfused. Small white arrows indicate nonperfused capillary segments (b). Nonperfused capillaries rapidly regress within 24 hours. Note large nonperfused areas in the control retinas and just a few individual nonperfused segments in Dll4-Fc-treated retinas. Green: GS lectin staining; red: tomato lectin perfusion [51].

(a)

(b)