Clinical Study
Impact of Baseline Central Retinal Thickness on Outcomes in the VIVID-DME and VISTA-DME Studies
Table 1
Baseline demographics of patient subgroups with baseline central retinal thickness < 400 μm or ≥400 μm (integrated data from VIVID-DME and VISTA-DME).
| | CRT < 400 μm | CRT ≥ 400 μm | | Laser control () | 2q4 () | 2q8 () | Laser control () | 2q4 () | 2q8 () |
| | Age (y), mean (SD) | 63.1 (9.2) | 61.5 (9.2) | 62.6 (8.2) | 62.5 (8.5) | 62.7 (10.4) | 64.0 (8.8) | | Sex (female) | 36 (46.2) | 42 (46.7) | 35 (44.9) | 87 (41.8) | 78 (39.0) | 85 (40.9) | | Race | | | | | | | | White | 69 (88.5) | 74 (82.2) | 67 (85.9) | 168 (80.8) | 163 (81.5) | 164 (78.8) | | Other/not reported | 9 (11.5) | 16 (17.8) | 11 (14.1) | 40 (19.2) | 37 (18.5) | 44 (21.2) | | HbA1c, mean (SD) | 7.96 (1.94) | 8.08 (1.55) | 7.98 (1.64) | 7.50 (1.28) | 7.77 (1.56) | 7.74 (1.44) | | Duration of diabetes (y), mean (SD) | 17.7 (10.1) | 17.2 (10.3) | 15.7 (10.0) | 15.5 (9.6) | 14.9 (9.4) | 16.5 (10.9) | | BCVA (letters), mean (SD) | 63.5 (8.2) | 63.1 (8.6) | 63.0 (8.3) | 59.0 (11.4) | 58.3 (11.3) | 57.7 (11.6) | | <40 letters | 1 (1.3) | 1 (1.1) | 1 (1.3) | 21 (10.1) | 19 (9.5) | 23 (11.1) | | ≥40 to <55 letters | 11 (14.1) | 19 (21.1) | 10 (12.8) | 35 (16.8) | 38 (19.0) | 41 (19.7) | | ≥55–65 letters | 19 (24.4) | 20 (22.2) | 30 (38.5) | 75 (36.1) | 70 (35.0) | 72 (34.6) | | ≥65 letters | 47 (60.3) | 50 (55.6) | 37 (47.4) | 77 (37.0) | 73 (36.5) | 72 (34.6) | | CRT (μm), mean (SD) | 338.8 (41.3) | 343.2 (36.1) | 337.9 (38.9) | 568.8 (132.2) | 555.1 (131.5) | 551.9 (135.9) | | DRSS score | | | | | | | | ≤43 | 29 (37.2) | 33 (36.7) | 32 (41.0) | 79 (38.0) | 63 (31.5) | 65 (31.3) | | 47 | 19 (24.4) | 17 (18.9) | 14 (17.9) | 31 (14.9) | 27 (13.5) | 45 (21.6) | | ≥53 | 30 (38.5) | 40 (44.4) | 32 (41.0) | 98 (47.1) | 109 (54.5) | 98 (47.1) | | BMI (kg/m2), mean | 31.48 | 30.04 | 31.72 | 30.02 | 30.97 | 30.02 |
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Values are n (%) unless otherwise noted. 2q4: 2 mg every 4 weeks; 2q8: 2 mg every 8 weeks; BCVA: best-corrected visual acuity; BMI: body mass index; CRT: central retinal thickness; DRSS: diabetic retinopathy severity scale; HbA1c: haemoglobin A1c; SD: standard deviation.
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