Optical Coherence Tomography Angiography to Distinguish Changes of Choroidal Neovascularization after Anti-VEGF Therapy: Monthly Loading Dose versus Pro Re Nata Regimen

Figure 1

OCTA follow-up of treatment-naïve choroidal neovascularization (CNV) associated to neovascular age-related macular degeneration (AMD) during the monthly loading anti-VEGF phase. Each column represents a visit; the upper row represents the quantification of CNV size on the outer retina to choriocapillaris (ORCC) slab; the lower row represents the comparison between baseline lesion area (yellow) and follow-up CNV area (red). Quantitative analysis demonstrated that at baseline, the area in the ORCC segmentation averaged 1.06 mm². Under anti-VEGF therapy, this area decreased significantly, to 0.55 mm², at month 1 (M1). At month 2 (M2), the area averaged 0.72 mm², while at month 3 (M3), at the end of the loading phase, the CNV area was 0.87 mm². Indeed, the CNV area decreased from baseline to month 3 by 17.39%. This decrease has been noticed on the overall cohort of treatment-naïve in a statistically significant manner (, Figure 3).