Optical Coherence Tomography Angiography to Distinguish Changes of Choroidal Neovascularization after Anti-VEGF Therapy: Monthly Loading Dose versus Pro Re Nata Regimen

Figure 2

OCTA follow-up of previously treated choroidal neovascularization (CNV) associated to neovascular age-related macular degeneration (AMD) during pro re nata (as needed) regimen. Each column represents a visit; the upper row represents the quantification of CNV size on the outer retina to choriocapillaris (ORCC) slab; the lower row represents the comparison between the baseline lesion area (yellow) and follow-up CNV area (blue). Quantitative analysis demonstrated that at baseline, the area in the ORCC segmentation averaged 1.93 mm². Under anti-VEGF therapy, this area decreased to 1.85 mm², at month 1(M1). At month 2 (M2), the area increased to 2.92 mm², while at month 3 (M3), at the last follow-up visit, the CNV averaged 2.45 mm². Indeed, the CNV area slightly increased from baseline to month 3 by 26.94%. This expansion of the CNV size in treated patients has been noticed on the overall cohort (, Figure 3).