Optical Coherence Tomography Angiography to Distinguish Changes of Choroidal Neovascularization after Anti-VEGF Therapy: Monthly Loading Dose versus Pro Re Nata Regimen

Figure 4

Illustrative drawing of suggested types of response to antiangiogenic treatment in CNV associated to neovascular AMD. Treatment-naïve, immature CNV, undergoing monthly loading phase, is depicted in red. Previously treated CNV, undergoing PRN, is depicted in blue. In the treatment-naïve eyes, there will be an initial response to treatment, characterized by regression (contraction) of the lesion area after each intravitreal injection (red dots). This initial response to anti-VEGF may be replaced after a variable amount of time(Δt) in an as needed protocol (PRN) by a late response in which, despite the disappearance of exudative signs of CNV, their area will continue to expand (blue dots). The latter type of response corresponds to a mature CNV.