Effect of Hyaluronic Acid/Trehalose in Two Different Formulations on Signs and Symptoms in Patients with Moderate to Severe Dry Eye Disease

Table 1

Changes in clinical signs and symptoms after 1 week treatment with either a gel containing hyaluronic acid, trehalose, and carbomer (HTC-gel) or eye drops containing hyaluronic acid (HT) PRN.

	HTC-gel		HT		value (time effect, ANOVA)
	Baseline	After 1-week treatment	Baseline	After 1-week treatment
Breakup time (s)	3.5 ± 1.7	4.2 ± 1.7	3.4 ± 1.4	4.3 ± 1.9	<0.001
Corneal fluorescein staining (0–15)	3.5 ± 2.3	2.7 ± 2.1	3.1 ± 1.7	2.2 ± 1.4	<0.001
Conjunctival lissamine green staining (0–18)	4.5 ± 2.8	3.5 ± 2.6	4.4 ± 2.5	2.8 ± 2.3	<0.001
Schirmer test I (mm)	11.6 ± 9.6	11.0 ± 9.2	12.2 ± 10.6	13.0 ± 10.4	0.88
Ocular surface disease index (OSDI, 0–100)	37.3 ± 21.4	36.1 ± 21.5	37.3 ± 19.9	33.4 ± 20.2	0.06