Effect of Hyaluronic Acid/Trehalose in Two Different Formulations on Signs and Symptoms in Patients with Moderate to Severe Dry Eye Disease
Table 2
Changes in the visual analogue scale (VAS) for each question after 1 week treatment with either a gel containing hyaluronic acid, trehalose, and carbomer (HTC-gel) or eye drops containing hyaluronic acid (HT) PRN.
Baseline
Study day
value (time effect, ANOVA)
value (between groups)
“What is your global satisfaction concerning your eyes when awakening in the morning?”
HT
26.9 ± 22.5
25.0 ± 22.8
0.48
0.59
HTC-gel
27.1 ± 26.0
26.8 ± 25.1
Feeling of swollen eyelid when awakening
HT
23.9 ± 23.8
21.9 ± 24.5
0.68
0.38
HTC-gel
24.9 ± 25.5
25.6 ± 25.2
Subjective evaluation of ocular comfort during the night
