Knockdown of Fibromodulin Inhibits Proliferation and Migration of RPE Cell via the VEGFR2-AKT Pathway

Figure 3

Effects of FMOD on the cell cycle and cell apoptosis in RPE cells. The results of the flow cytometry analysis revealed that FMOD-siRNA-treated RPE cells accumulated more in the G0/G1 phase but less in the G2/M and the S phase of the cell cycle compared with the NS-siRNA group: (a) NS-siRNA-treated RPE cells; (b) FMOD-siRNA-treated RPE cells; (c) statistical analysis of the cell cycle. The percentage of early apoptotic cells plus late apoptotic cells in the FMOD-siRNA-treated group was significantly lower than in the controls, indicating that FMOD depletion induced cell apoptosis in RPE cells: (d) NS-siRNA-treated RPE cells; (e) FMOD-siRNA-treated RPE cells; (f) statistical analysis of cell apoptosis. Data are presented as the means ± SEM. Each experiment was repeated at least three times. ; .

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