Efficacy of Osthole in Management of Hypoperfused Retina

Figure 7

Apoptosis, assessed by TUNEL assay. To evaluate retinal cell apoptosis, TUNEL was preformed (a). Semiquantitative analysis was performed by IOD/area (b). The level of retinal apoptosis was similar in the osthole-IG and model groups at day 5 and higher than in the other treated groups. But from day 10 onwards, less apoptosis was observed in the osthole-IG, and levels were almost decreased to those observed in the control group. In the osthole-PI group, apoptosis increased from day 10.

(a)

(b)