Manifestation of Clinical Categories of Ocular Graft-versus-Host Disease

Table 1

Demographics and transplant characteristic by patient groups.

	Acute GVHD	Chronic GVHD
	(, eyes = 42)	(, eyes = 254)
Age (yrs.), mean ± SD	29 ± 12	28 ± 11
(independent sample T-test)	0.704
Gender
Male	13 (61.9%)	79 (62.2%)
Female	8 (38.1%)	48 (37.8%)
(chi-square test)	0.979
Primary disease
Acute lymphoid leukemia	2 (9.5%)	38 (29.9%)
Acute myeloid leukemia	9 (42.9%)	48 (37.8%)
Myelodysplastic syndrome	6 (28.6%)	31 (24.4%)
Chronic myeloid leukemia	1 (4.8%)	5 (3.9%)
Non-Hodgkin’s lymphoma	0 (0.0%)	3 (2.4%)
Hodgkin’s lymphoma	1 (4.8%)	0 (0.0%)
Aplastic anemia	2 (9.5%)	2 (1.6%)
Donor-recipient gender disparity
Female donor to male recipient	8 (38.1%)	36 (28.3%)
Male donor to female recipient	4 (19.0%)	33 (26.0%)
Essential time points
Interval from transplant to initial ocular symptoms (months), mean ± SD	8.0 ± 5.0	10.7 ± 9.1
(Mann–Whitney U test)	0.091
Interval between initial symptoms and first visit (months), mean ± SD	0.6 ± 0.7	9.9 ± 14.1
(Mann–Whitney U test)	<0.001
Interval between transplant and first visit (months), mean ± SD	8.6 ± 5.4	20.4 ± 17.7
(Mann–Whitney U test)	<0.001

GVHD = graft-versus-host disease.