Effect of Exogenous Alpha-B Crystallin on the Structures and Functions of Trabecular Meshwork Cells

<div>Effect of CRYAB on the expression of zo-1 and claudin-1 in TM cells. (a) Immunofluorescence manifestation of zo-1 and claudin-1. Immunofluorescence verified the upregulation of tight junction proteins (A: zo-1; B: claudin-1). (b) Western blot analysis of zo-1 expression. TM cells were exposed to 10 ng/ml CRYAB for 24 h. The expression of zo-1 increased under CRYAB conditions compared with the control. (c) Rt-qPCR analysis of zo-1 and claudin-1 mRNA expression. Compared with that of the control, the expression of zo-1 and claudin-1 was upregulated in response to CRYAB. 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Journal of Ophthalmology

fig4

Figure 4

Figure 4: Effect of Exogenous Alpha-B Crystallin on the Structures and Functions of Trabecular Meshwork Cells 