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Journal of Ophthalmology
Volume 2018, Article ID 8025951, 6 pages
Research Article

Vascular Endothelial Growth Factor, Basic Fibroblast Growth Factor, and Pigment Epithelium-Derived Factor Expression in the Neovascular Iris in Retinal Diseases

1Department of Ophthalmology, People’s Hospital, Peking University, Beijing, China
2Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan
3Department of Ophthalmology, School of Medicine, National Yang-Ming University, Taipei, Taiwan
4Department of Ophthalmology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China

Correspondence should be addressed to De-Kuang Hwang; moc.liamg@kbg59m and Yong Tao; moc.361@gnoyoatrd

Received 1 September 2017; Revised 7 February 2018; Accepted 13 March 2018; Published 11 April 2018

Academic Editor: Lisa Toto

Copyright © 2018 Heng Miao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. To determine the expression of cytokines in the iris of patients with neovascular glaucoma (NVG). Methods. Patients with NVG associated with proliferative diabetic retinopathy (PDR, group 1) or central retinal vein occlusion (CRVO, group 2) who had undergone surgical treatment were enrolled. Patients with primary open-angle glaucoma requiring surgical treatment were included in the control group (group 3). All iris specimens were obtained during trabeculectomy, 7 days after intravitreal injections of ranibizumab. The messenger RNA (mRNA) and protein levels of three target cytokines—vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), and pigment epithelium-derived factor (PEDF)—in the iris were analyzed and compared. Results. We included 39 eyes from 39 patients (12, 15, and 12 in groups 1, 2, and 3, resp.). The protein and mRNA levels of PEDF were higher in two NVG groups. The protein levels, but not mRNA level, of bFGF were higher in the two NVG groups. The protein and mRNA levels of VEGF were similar in the three groups. Conclusions. The protein level of bFGF increased in the irises of the NVG patients was not expressed by the iris itself, whereas PEDF may be expressed by the iris tissue in these patients.