Research Article
Risk of Ischemic Stroke, Hemorrhagic Stroke, and All-Cause Mortality in Retinal Vein Occlusion: A Nationwide Population-Based Cohort Study
Table 1
Characteristics of the study subjects.
| | Variable | RVO group | Comparison group (real world) | -value | Comparison group (PS-matched) | -value | | n = 22919 | n = 114595 | n = 114595 |
| | Age, year (mean±SD) | 61.8 ± 13.0 | 43.2 ± 15.4 | <0.0001 | 61.8 ± 13.0 | >0.99 |
| | Age, categorical | | | <0.0001 | | >0.99 | | <50 | 3895 (17.0) | 78047 (68.1) | | 19487 (17.0) | | | 50-60 | 5700 (24.9) | 18802 (16.4) | | 28300 (24.9) | | | 60-70 | 6140 (26.8) | 9819 (8.6) | | 30795 (26.8) | | | >=70 | 7184 (31.3) | 7927 (6.9) | | 36013 (31.3) | |
| | Gender | | | 0.04 | | 0.99 | | Male | 11801 (51.5) | 58090 (50.7) | | 59015 (51.5) | | | Female | 11118 (48.5) | 56505 (49.3) | | 55080 (48.5) | |
| | Antithrombotic drugs | 6437 (28.1) | 8776 (7.7) | <0.0001 | 32175 (28.1) | 0.99 |
| | Comorbidities | | | | | | | Obesity | 657 (2.9) | 2388 (2.1) | <0.0001 | 3346 (2.9) | 0.67 | | Diabetes | 8635 (37.7) | 14468 (12.6) | <0.0001 | 43090 (37.6) | 0.84 | | Hypertension | 17927 (78.2) | 28935 (25.2) | <0.0001 | 89623 (78.2) | 0.98 | | Hyperlipidemia | 10991 (48.0) | 22688 (19.8) | <0.0001 | 55005 (48.0) | 0.91 | | Coronary artery disease | 8173 (35.7) | 12223 (10.7) | <0.0001 | 40909 (35.7) | 0.92 | | Atrial fibrillation | 973 (4.2) | 1113 (1.0) | <0.0001 | 4809 (4.2) | 0.75 | | Chronic kidney disease | 2724 (11.9) | 2468 (2.2) | <0.0001 | 13646 (11.9) | 0.93 | | Hyperviscosity | 252 (1.1) | 344 (0.3) | <0.0001 | 1260 (1.1) | >0.99 |
| | CCI | | | <0.0001 | | >0.99 | | 0 | 17017 (74.3) | 105002 (91.6) | | 85150 (74.3) | | | 1 | 2668 (11.6) | 5022 (4.4) | | 13300 (11.6) | | | 2 | 1673 (7.3) | 2615 (2.3) | | 8353 (7.3) | | | ≥3 | 1561 (6.8) | 1956 (1.7) | | 7792 (6.8) | |
| | Glaucoma | 2016 (8.8) | 1718 (1.5) | <0.0001 | 10084 (8.8) | 0.99 |
| | PS | 0.11 ± 0.07 | | | 0.11 ± 0.07 | 1.00 |
| | Stroke | | | | | | | Incident event | 5481 (23.9) | 7523 (6.6) | <0.0001 | 22235 (19.4) | <0.0001 | | Mean follow-up year | 4.9 ± 3.5 | 6.2 ± 3.7 | <0.0001 | 5.4 ± 3.5 | <0.0001 |
| | Ischemic stroke | | | | | | | Incident event | 4867 (21.2) | 6583 (5.7) | <0.0001 | 19742 (17.2) | <0.0001 | | Mean follow-up year | 4.8 ± 3.5 | 6.2 ± 3.7 | <0.0001 | 5.4 ± 3.5 | <0.0001 |
| | Hemorrhagic stroke | | | | | | | Incident event | 813 (3.5) | 1153 (1.0) | <0.0001 | 3063 (2.7) | <0.0001 | | Mean follow-up year | 5.7 ± 3.5 | 6.4 ± 3.7 | <0.0001 | 5.7 ± 3.6 | 0.54 |
| | All-cause mortality | | | | | | | Incident event | 3111 (13.6) | 7972 (7.0) | <0.0001 | 15106 (13.2) | 0.11 | | Mean follow-up year | 5.8 ± 3.6 | 6.5 ± 3.7 | | 5.8 ± 3.7 | 0.63 |
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Data are presented in number (percentage) or mean ± SD. RVO = retinal vein occlusion; PS = propensity score; CCI = Charlson comorbidity index.
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