Combined Application of Bevacizumab and Mitomycin C or Bevacizumab and 5-Fluorouracil in Experimental Glaucoma Filtration Surgery

Figure 7

Histological features of filtering positions after 56 days (magnification ratio ×100). (a–f) Hematoxylin and eosin (H&E) staining, (g–l) Masson staining of the tissue sections. In the control (a and g) and 5-fluorouracil (5-Fu) treatment groups (c and i), the subconjunctival fibrous scar tissues were dense. The collagen deposition was relatively loose in the bevacizumab (BVZ) treatment group (b and h), and the structures of filtering blebs could not be distinguished in the three groups. In the mitomycin C (MMC) (d and j), 5-FU + BVZ (e and k), and MMC + BVZ (f and l) treatment groups, the subconjunctival collagen deposition was spare, and the residual filtering bleb structure was observed in all these groups. CB, ciliary body; C, conjunctiva; SS, scleral excision position.

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