DNA Methylation Status of the Interspersed Repetitive Sequences for LINE-1, Alu, HERV-E, and HERV-K in Trabeculectomy Specimens from Glaucoma Eyes
Table 1
Demographic and clinical characteristics of the subjects.
Normal control
POAG
PACG
Secondary glaucoma
N
10
16
12
16
Age
Mean (SD)
40 (20.8)
69 (8.1)
65 (10.0)
53 (15.0)
Gender, male
N (%)
5 (50.0)
11 (64.7)
2 (15.4)
9 (56.3)
Laterality, right
N (%)
5 (50.0)
9 (52.9)
7 (58.3)
8 (50.0)
Duration (month)
Median (IQR)
—
36.0 (24.0, 84.0)
12 (7.0, 132.0)
2.5 (1.75, 9.75)
Vertical C : D ratio
Median (IQR)
—
0.9 (0.8, 0.9)
0.8 (0.8, 0.9)
0.8 (0.7, 0.9)
IOP (mmHg)
Mean (SD)
—
20 (8.1)
21.6 (9.8)
33.3 (13.0)
VA (decimal)
Median (IQR)
—
0.677 (0.200, 1.000)
0.500 (0.100, 0.700)
0.015 (0.001, 0.400)
Number of medication
Median (IQR)
—
4.0 (3.75, 4.0)
4.0 (4.0, 4.3)
4.0 (4.0, 5.0)
Visual field MD
Median (IQR)
—
−11.31 (−16.98, −9.43)
−10.62 (−14.85, −4.50)
NA
Visual field PSD
Median (IQR)
—
7.75 (3.31, 8.21)
7.59 (1.98, 9.22)
NA
POAG = primary open-angle glaucoma; PACG = primary angle-closure glaucoma; C : D = optic cup to optic disc ratio; VA = visual acuity; MD = mean deviation; PSD = pattern standard deviation; NA = not applicable due to poor visual acuity.
