Trabeculectomy and EX-PRESS Implantation in Open-Angle Glaucoma: An Updated Meta-Analysis of Randomized Controlled Trials

Table 2

Subgroup analysis of IOPR% from the baseline to the endpoint comparing trabeculectomy and EX-PRESS.

Group	No. of studies	MD			Test for heterogeneity			Test for overall effect
		Estimate	Lower	Up	χ2	I^2 (%)		Z
All	8	3.60	−3.11	10.31	14.49	52	0.04	1.05	0.29
Follow-up
≤24 months	5	5.23	−3.50	13.96	10.96	64	0.03	1.17	0.24
>24 months	3	0.23	−9.15	9.60	1.82	0	0.40	0.05	0.96
Sample size (each group)
≤30	4	11.52	6.14	16.89	2.75	0	0.43	4.20	<0.0001
>30	4	−1.37	−7.46	4.73	2.10	0	0.55	0.44	0.66
Publication year
Before 2014	3	−0.56	−7.44	6.31	1.43	0	0.49	0.16	0.87
After 2014	5	5.72	−3.00	14.44	7.91	49	0.09	1.29	0.20
Mitomycin-C concentration
<0.4 mg/ml	3	4.14	−5.51	13.78	4.42	55	0.11	0.84	0.40
≥0.4 mg/ml	4	2.54	−9.38	14.46	7.60	61	0.05	0.42	0.68
Unknown	1	−3.37	−29.54	22.8	—	—	—	0.25	0.80