COL11A1 Polymorphisms Are Associated with Primary Angle-Closure Glaucoma Severity
Table 3
Single-nucleotide polymorphism allele frequencies and associations for 12 SNPs between cases and controls.
SNP
CHR
BP
MA
MAF case
MAF control
values
OR (95% CI)
rs1676486
1
103354138
A
0.32
0.19
0.026
2.089 (1.092–3.996)
rs3753841
1
103379918
G
0.39
0.26
0.036
1.886 (1.038–3.426)
rs12138977
1
103393457
C
0.31
0.18
0.024
2.133 (1.104–4.123)
rs2126642
1
103405793
A
0.11
0.10
0.818
1.112 (0.450–2.746)
rs2622848
1
103421003
C
0.10
0.07
0.449
1.475 (0.539–4.040)
rs216489
11
16823736
G
0.41
0.38
0.668
1.131 (0.645–1.982)
rs1027617
11
16842787
A
0.38
0.45
0.321
0.754 (0.431–1.317)
rs366590
11
16872440
A
0.23
0.20
0.607
1.194 (0.608–2.343)
rs11024060
11
16881961
T
0.29
0.36
0.297
0.732 (0.407–1.316)
rs6486330
11
16990290
T
0.20
0.19
0.859
1.065 (0.530–2.142)
rs11024097
11
16999029
C
0.36
0.45
0.200
0.693 (0.395–1.215)
rs11024102
11
17008605
C
0.44
0.41
0.671
1.128 (0.647–1.965)
Chi-square tests and logistic regression were used. CHR: chromosome; BP: base pair position; MA: minor allele; MAF: minor allele frequency; MAF Case: minor allele frequencies in cases; MAF Control: minor allele frequencies in controls; OR: odds ratio; CI: confidence interval.
