COL11A1 Polymorphisms Are Associated with Primary Angle-Closure Glaucoma Severity

Table 4

Single nucleotide polymorphism genotype frequencies and associations for 12 SNPs between cases and controls.

SNP	Genotype	Case		Control		values	OR (95% CI)
		N	%	N	%
rs1676486	GG	21	41.20	32	62.70	1
	AG	27	52.90	19	37.3	0.060	2.165 (0.968–4.842)
	AA	3	5.88	0	0	—	—
	AG + AA	30	58.8	19	37.3	0.031	2.406 (1.086–5.332)
rs3753841	AA	19	37.3	27	52.9	1
	AG	24	47.1	22	43.1	0.297	1.550 (0.680–3.534)
	GG	8	15.7	2	3.92	0.040	5.684 (1.084–29.803)
	AG + GG	32	72.4	24	47.1	0.11	0.528 (0.239–1.163)
rs12138977	TT	22	43.1	33	64.7	1
	CT	26	51.0	18	35.3	0.061	2.167 (0.966–4.859)
	CC	3	5.9	0	0	—	—
	CT + CC	29	56.9	18	35.3	0.030	2.417 (1.088–5.368)
rs2126642	GG	40	78.4	42	82.4	1
	AG	11	21.6	8	15.7	0.475	1.444 (0.527–3.958)
	AA	0	0	1	2.0	—	—
	AG + AA	11	21.6	9	17.6	0.618	1.283 (0.481–3.425)
rs2622848	TT	42	82.4	44	86.3	1
	CT	8	15.7	7	13.7	0.748	1.197 (0.399–3.593)
	CC	1	2.0	0	0	—	—
	CT + CC	9	17.6	7	13.70	0.587	1.347 (0.460–3.944)
rs216489	AA	17	0.33	21	0.41	1
	AG	26	0.51	21	0.41	0.333	1.529 (0.647–3.614)
	GG	8	0.16	9	0.18	0.873	1.098 (0.349–3.458)
	AG + GG	34	0.67	30	0.59	0.413	1.4 (0.625–3.135)
rs1027617	GG	20	0.39	14	0.27	1
	AG	23	0.45	28	0.55	0.427	1.607 (0.498–5.188)
	AA	8	0.16	9	0.18	0.888	0.924 (0.307–2.778)
	AG + AA	31	0.61	37	0.73	0.209	0.586 (0.255–1.349)
rs366590	GG	31	0.61	35	0.69	1
	AG	17	0.33	12	0.24	0.297	1.599 (0.661–3.868)
	AA	3	0.06	4	0.08	0.836	0.847 (0.176–4.083)
	AG + AA	20	0.39	16	0.31	0.408	1.411 (0.624–3.192)
rs11024060	CC	25	0.49	23	0.45	1
	CT	22	0.43	19	0.37	0.882	1.065 (0.462–2.456)
	TT	4	0.08	9	0.18	0.18	0.409 (0.111–1.511)
	CT + TT	26	0.51	28	0.55	0.692	1.171 (0.538–2.549)
rs6486330	CC	35	0.69	34	0.67	1
	CT	12	0.24	15	0.29	0.58	0.777 (0.318–1.9)
	TT	4	0.08	2	0.04	0.46	1.943 (0.334–11.313)
	CT + TT	16	0.31	17	0.33	0.832	0.914 (0.399–2.097)
rs11024097	TT	24	0.47	14	0.27	1
	CT	17	0.33	28	0.55	0.039	0.391 (0.161–0.953)
	CC	10	0.2	9	0.18	0.493	0.676 (0.221–2.071)
	CT + CC	27	0.53	37	0.73	0.066	0.461 (0.202–1.052)
rs11024102	TT	17	0.33	18	0.35	1
	CT	23	0.45	24	0.47	0.898	1.059 (0.443–2.531)
	CC	11	0.22	9	0.18	0.776	1.176 (0.385–3.599)
	CT + CC	34	0.67	34	0.67	0.835	1.091 (0.482–2.471)

Logistic regression was used.