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Journal of Ophthalmology
Volume 2019, Article ID 3054758, 15 pages
https://doi.org/10.1155/2019/3054758
Research Article

Retinal and Corneal Toxicity and Pharmacokinetic Analysis of Intraocular Injection of Ganciclovir in Rabbit Eyes

Department of Ophthalmology, Peking University Third Hospital, Beijing 100191, China

Correspondence should be addressed to Jing Hong; moc.361@104691gnijgnoh

Received 15 November 2018; Revised 28 March 2019; Accepted 21 April 2019; Published 7 May 2019

Academic Editor: Hong Liang

Copyright © 2019 Bin-jia Sun et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. K. Field, M. E. Davies, C. DeWitt et al., “9-([2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine: a selective inhibitor of herpes group virus replication,” Proceedings of the National Academy of Sciences, vol. 80, no. 13, pp. 4139–4143, 1983. View at Publisher · View at Google Scholar
  2. A. Alfawaz, “Cytomegalovirus-related corneal endotheliitis: a review article,” Saudi Journal of Ophthalmology, vol. 27, no. 1, pp. 47–49, 2013. View at Publisher · View at Google Scholar · View at Scopus
  3. N. Koizumi, D. Miyazaki, T. Inoue et al., “The effect of topical application of 0.15% ganciclovir gel on cytomegalovirus corneal endotheliitis,” British Journal of Ophthalmology, vol. 101, no. 2, pp. 114–119, 2017. View at Publisher · View at Google Scholar · View at Scopus
  4. M. L. Occhiutto, F. R. Freitas, R. C. Maranhao, and V. P. Costa, “Breakdown of the blood-ocular barrier as a strategy for the systemic use of nanosystems,” Pharmaceutics, vol. 4, no. 2, pp. 252–275, 2012. View at Publisher · View at Google Scholar · View at Scopus
  5. B. C. Marshall and W. C. Koch, “Antivirals for cytomegalovirus infection in neonates and infants,” Pediatric Drugs, vol. 11, no. 5, pp. 309–321, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. K. Yutthitham and P. Ruamviboonsuk, “The high-dose, alternate-week intravitreal ganciclovir injections for cytomegalovirus retinitis in acquired immune deficiency syndrome patients on highly active antiretroviral therapy,” Journal of the Medical Association of Thailand, vol. 88, no. 9, pp. S63–S68, 2005. View at Google Scholar
  7. S.-P. Chee and A. Jap, “Treatment outcome and risk factors for visual loss in Cytomegalovirus endotheliitis,” Graefe’s Archive for Clinical and Experimental Ophthalmology, vol. 250, no. 3, pp. 383–389, 2012. View at Publisher · View at Google Scholar · View at Scopus
  8. W. S. Choi, J. H. Cho, H. K. Kim, H. S. Kim, and Y. J. Shin, “A case of CMV endotheliitis treated with intravitreal ganciclovir injection,” Korean Journal of Ophthalmology, vol. 27, no. 2, pp. 130–132, 2013. View at Publisher · View at Google Scholar · View at Scopus
  9. E. Sakurai, Y. Matsuda, H. Ozeki, N Kunou, K Nakajima, and Y Ogura, “Scleral plug of biodegradable polymers containing ganciclovir for experimental cytomegalovirus retinitis,” Investigative Opthalmology & Visual Science, vol. 42, no. 9, pp. 2043–2048, 2001. View at Google Scholar
  10. C. Durairaj, “Ocular pharmacokinetics,” in Handbook of Experimental Pharmacology, vol. 242, pp. 31–55, Springer, Berlin, Germany, 2017. View at Publisher · View at Google Scholar · View at Scopus
  11. J. Schulman, G. A. Peyman, M. B. Horton et al., “Intraocular 9-([2-hydroxy-1-(hydroxymethyl) ethoxy] methyl) guanine levels after intravitreal and subconjunctival administration,” Ophthalmic Surgery, vol. 17, 1986. View at Google Scholar
  12. G. A. Peyman, B. Khoobehi, M. Tawakol et al., “Intravitreal injection of liposome-encapsulated ganciclovir in a rabbit model,” Retina, vol. 7, no. 4, pp. 227–229, 1987. View at Publisher · View at Google Scholar · View at Scopus
  13. J. J. Zhang, C. F. Gao, and L. Y. Wang, “Ocular pharmacokinetics and bioavailability of 0.2% ganciclovir in-situ gelling eye drops,” Zhonghua Yan Ke Za Zhi, vol. 42, no. 7, pp. 637–641, 2006. View at Google Scholar
  14. T. Y. Chou and B. Y. Hong, “Ganciclovir ophthalmic gel 0.15% for the treatment of acute herpetic keratitis: background, effectiveness, tolerability, safety, and future applications,” Therapeutics and Clinical Risk Management, vol. 10, pp. 665–681, 2014. View at Publisher · View at Google Scholar · View at Scopus
  15. D. Ghate and H. F. Edelhauser, “Ocular drug delivery,” Expert Opinion on Drug Delivery, vol. 3, no. 2, pp. 275–287, 2006. View at Publisher · View at Google Scholar · View at Scopus
  16. S. Gunda, S. Hariharan, and A. K. Mitra, “Corneal absorption and anterior chamber pharmacokinetics of dipeptide monoester prodrugs of ganciclovir (GCV): in vivo comparative evaluation of these prodrugs with Val-GCV and GCV in rabbits,” Journal of Ocular Pharmacology and Therapeutics, vol. 22, no. 6, pp. 465–476, 2006. View at Publisher · View at Google Scholar · View at Scopus
  17. J. F. Arevalo, R. A. Garcia, and A. J. Mendoza, “High-dose (5000-μg) intravitreal ganciclovir combined with highly active antiretroviral therapy for cytomegalovirus retinitis in HIV-infected patients in Venezuela,” European Journal of Ophthalmology, vol. 15, no. 5, pp. 610–618, 2005. View at Publisher · View at Google Scholar
  18. S. Ausayakhun, P. Yuvaves, S. Ngamtiphakorn et al., “Treatment of cytomegalovirus retinitis in AIDS patients with intravitreal ganciclovir,” Journal of the Medical Association of Thailand, vol. 88, no. 9, pp. S15–S20, 2005. View at Google Scholar
  19. P. Choopong, K. Vivittaworn, D. Konlakij, S. Thoongsuwan, A. Pituksung, and N. Tesavibul, “Treatment outcomes of reduced-dose intravitreal ganciclovir for cytomegalovirus retinitis,” BMC Infectious Diseases, vol. 16, no. 1, pp. 1–7, 2016. View at Publisher · View at Google Scholar · View at Scopus
  20. I. Cochereau-Massin, P. Lehoang, M. Lautier-Frau et al., “Efficacy and tolerance of intravitreal ganciclovir in cytomegalovirus retinitis in acquired immune deficiency syndrome,” Ophthalmology, vol. 98, no. 9, pp. 1348–1355, 1991. View at Publisher · View at Google Scholar · View at Scopus
  21. S. C. Teoh, X. Ou, and T. H. Lim, “Intravitreal ganciclovir maintenance injection for cytomegalovirus retinitis: efficacy of a low-volume, intermediate-dose regimen,” Ophthalmology, vol. 119, no. 3, pp. 588–595, 2012. View at Publisher · View at Google Scholar · View at Scopus
  22. G. Velez, C. E. Roy, S. M. Whitcup, C.-C. Chan, and M. R. Robinson, “High-dose intravitreal ganciclovir and foscarnet for cytomegalovirus retinitis,” American Journal of Ophthalmology, vol. 131, no. 3, pp. 396-397, 2001. View at Publisher · View at Google Scholar · View at Scopus
  23. P. Choopong, N. Tesavibul, and N. Rodanant, “Crystallization after intravitreal ganciclovir injection,” Clinical Ophthalmology, vol. 4, pp. 709–711, 2010. View at Publisher · View at Google Scholar
  24. J. Pulido, G. A. Peyman, T. Lesar, and J. Vernot, “Intravitreal toxicity of hydroxyacyclovir (BW-B759U), a new antiviral agent,” Archives of Ophthalmology, vol. 103, no. 6, pp. 840-841, 1985. View at Publisher · View at Google Scholar · View at Scopus
  25. G. A. Peyman, J. A. Schulman, B. Khoobehi, H. M. Alkan, M. E. Tawakol, and H. Mani, “Toxicity and clearance of a combination of liposome-encapsulated ganciclovir and trifluridine,” Retina, vol. 9, no. 3, pp. 232–236, 1989. View at Publisher · View at Google Scholar · View at Scopus
  26. M. Moschos, M. Vamvasakis, G. Kontogeorgos, F. Papantonis, E. Panagakis, and V. Chatzis, “Intravitreal application of ganciclovir in rabbits: erg and electron-microscopic findings,” Ophthalmologica, vol. 210, no. 4, pp. 215–222, 1996. View at Publisher · View at Google Scholar · View at Scopus
  27. J. Chen, Z. Li, L. Zhang et al., “Descemet’s membrane supports corneal endothelial cell regeneration in rabbits,” Scientific Reports, vol. 7, no. 1, pp. 1–13, 2017. View at Publisher · View at Google Scholar · View at Scopus
  28. W. S. Choi, J. W. Koh, T. Y. Chung, J. Y. Hyon, W. R. Wee, and Y. J. Shin, “Cytotoxicity of ganciclovir on cultured human corneal endothelial cells,” Antiviral Therapy, vol. 18, no. 6, pp. 813–820, 2013. View at Publisher · View at Google Scholar · View at Scopus