Association between Platelet Parameters and Glaucoma Severity in Primary Open-Angle Glaucoma

Table 3

Comparison of demographics, platelet parameters, and ocular parameters in subjects with POAG, stratified according to severity.

Factors	Mild POAG ()	Moderate POAG ()	Severe POAG ()	value
Age (y)	50.53 ± 16.00	51.83 ± 15.60	50.74 ± 15.66	0.882
Female/male	24/46	37/57	73/165	0.313
BMI	23.21 ± 2.79	23.58 ± 2.91	24.92 ± 3.68	0.048^b
IOP (mm·Hg)	19.30 ± 6.60	20.43 ± 8.53	25.74 ± 11.21	<0.001^bc
VCDR	0.60 ± 0.20	0.71 ± 0.19	0.87 ± 0.13	<0.001^abc
MD (dB)	4.13 ± 1.28	9.34 ± 1.61	22.45 ± 5.53	<0.001^abc
MS (dB)	23.39 ± 1.45	18.25 ± 1.87	6.24 ± 4.95	<0.001^abc
PLT (10^9/L)	217.43 ± 48.11	218.16 ± 54.98	200.77 ± 52.18	0.036^c
PDW (fL)	11.82 ± 2.44	12.50 ± 3.14	14.49 ± 2.99	<0.001^bc
PCT (%)	0.21 ± 0.04	0.22 ± 0.05	0.21 ± 0.05	0.744
MPV (fL)	9.92 ± 0.76	10.02 ± 1.08	10.74 ± 1.39	<0.001^bc
P-LCR (%)	24.35 ± 5.90	24.58 ± 7.41	30.12 ± 9.71	0.001^bc

χ² test and 1-way analysis of variance (ANOVA) were used. Data are expressed as mean ± SD. ^a for the difference between Mild POAG and Moderate POAG (1-way ANOVA with the LSD post hoc test). ^b for the difference between Mild POAG and Severe POAG (1-way ANOVA with the LSD post hoc test). ^c for the difference between Moderate POAG and Severe POAG (1-way ANOVA with the LSD post hoc test). POAG: primary open-angle glaucoma; BMI: body mass index; IOP, intraocular pressure; VCDR, vertical cup-disc ratio; MD, visual field mean deviation; MS, visual fields mean sensitivity; PLT: platelet count; PDW: platelet distribution width; PCT: plateletcrit; MPV: mean platelet volume; P-LCR: platelet large cell ratio.