Research Article
Different Characteristics of Aquaporin-4 and Myelin Oligodendrocyte Glycoprotein Antibody-Seropositive Male Optic Neuritis in China
Table 2
Demographic and clinical characteristics in male patients with AQP4- and MOG-ON.
| | | AQP4-ON | MOG-ON | value |
| | No. of patients, n (%) | 32 (42.1) | 44 (57.9) | | | No. of eyes | 57 | 75 | | | Mean age at onset (range) | 36.4 (12–72) | 20.3 (3–61) | <0.001 | | Age at first attack <18 years (n, %) | 3 (9.4) | 26 (59.1) | <0.001 | | Bilaterality at first onset, n (%) | 6 (18.8) | 13 (29.5) | 0.283 | | Ocular pain, n (%) | 17 (53.1) | 30 (68.2) | 0.182 | | Optic disc swelling, n (%) | 5 (15.6) | 17 (38.6) | 0.040 | | Abnormal autoimmune antibody, n (%) | 12 (37.5) | 6 (13.6) | 0.016 | | ANA | 8 (25.0) | 0 (0.0) | | | HLA-B27 | 1 (3.1) | 2 (4.5) | | | ATAs/anti-TPOAb | 4 (12.5) | 2 (4.5) | | | Anti-SSA/anti-SSB | 0 (0.0) | 0 (0.0) | | | ACL/β2-GPI | 3 (9.4) | 2 (4.5) | | | ANCA | 0 (0.0) | 0 (0.0) | | | RF | 0 (0.0) | 0 (0.0) | | | APF | 1 (3.1) | 0 (0.0) | | | No. of lumbar punctures | 27 | 37 | | | CSF white cell count, mean ± SD (n/mm3) | 2.81 ± 3.16 | 6.32 ± 20.14 | 0.374 | | White cell counts elevated | 1 (3.7) | 4 (10.8) | 0.387 | | CSF protein, mean ± SD (g/L) | 437.3 ± 141.9 | 360.8 ± 119.9 | 0.024 | | Protein elevated | 15 (57.7) | 15 (40.5) | 0.180 | | CSF IgG level, mean ± SD (mg/dL) | 3.46 ± 1.54 | 2.43 ± 1.15 | 0.003 | | IgG level elevated | 12 (46.2) | 6 (16.2) | 0.010 |
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; ; ANA, antinuclear antibody; HLA-B27, human leukocyte antigen-B27; ATAs, antithyroglobulin antibodies; anti-TPOAb, antithyroid peroxidase autoantibody; anti-SSA and SSB, anti-Sjögren’s syndrome A and B; ACL, anticardiolipin antibody; β2-GPI, anti- β2-glycoprotein I; ANCA, antineutrophil cytoplasmic antibodies; RF, rheumatoid factor; APF, antiperinuclear factor; CSF, cerebrospinal fluid; ON, optic neuritis. |
