Journal of Ophthalmology

Review Article

Pain Perception of the First Eye versus the Second Eye during Phacoemulsification under Local Anesthesia for Patients Going through Cataract Surgery: A Systematic Review and Meta-Analysis

Table 1

Characteristics of included studies.
Author YearCountryNumber of eligible patientsMean age (year)Number of excluded patientsConsecutive recruitmentBlind methodSelf-comparisonInterval of bilateral eye surgeries (week)Time of assessing painOutcome of painMeasure of painLocal anesthesiaLocal anesthesia drugAdditional anesthesiaTime of assessing anxietyOutcome of anxietyMeasure of anxietyNumber of surgeons
Sharma et al. 2008 [11]Australia127NA2YesNANoNA1NoVASTopical1% amethocaine + 1% ropivacaine—1NoVAS1
Bardocci et al. 2011 [6]Australia7375.28YesNAYes0.86–23.1 SD: 220NoVASTopical2% xylocaine————1
Ursea et al. 2011 [12]USA6564NAYesYesYes1–32 SD: 60SecondVASTopicalNA—0FirstAPAIS/STAI1
1No
Hari-Kovacs et al. 2012 [5]UK18776.513YesNAYes9.99–16.60NoVASTopical0.5% proximetacaineHydrodissection with lidocaine———1
Asian et al. 2013 [13]Turkey6068.45/70.863YesYesYes0–120SecondVASTopical0.5% proparacaineIntracameral anesthesia with lidocaine———1
Jiang et al. 2015 [14]China15967/698NANANoNA0SecondVASTopical2% lidocaine—0NoVAS/STAI1
Akkaya et al. 2016 [4]Turkey26868.7NAYesYesYes0–120SecondVASSub-Tenon’s2% lidocaine + 0.75% bupivacaine————4
Zhang et al. 2018 [3]China3866.6NAYesYesYes0–80SecondVASTopicalNA————1
VAS: visual analogue scale; Amsterdam Preoperative Anxiety and Information Scale (APAIS); State-Trait Anxiety Scale (STAI); NA: not available. Time of assessing pain and anxiety: 0 on the day of the surgery; 1 the day after the surgery. Outcome of pain and anxiety: first: first eye is more painful (anxious); second: second eye is more painful (anxious); no: no difference.