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Journal of Ophthalmology
Volume 2019, Article ID 4806061, 8 pages
Research Article

Relationship between Neovascular Density in Swept Source-Optical Coherence Tomography Angiography and Signs of Activity in Exudative Age-Related Macular Degeneration

1Karl Landsteiner Institute for Retinal Research and Imaging, Vienna, Austria
2Department of Ophthalmology, Rudolf Foundation Hospital, Vienna 1030, Juchgasse 25, Austria
3Center for Medical Statistic, Informatics, and Intelligent Systems, Medical University of Vienna, Vienna 1090, Spitalgasse 23, Austria
4Department of Ophthalmology, Medical University of Graz, Graz 8036, Auenbruggerplatz 1, Austria

Correspondence should be addressed to Siamak Ansari-Shahrezaei; ta.vakneiw@ieazerhahs-irasna.kamais

Received 8 February 2019; Revised 7 May 2019; Accepted 16 May 2019; Published 9 July 2019

Academic Editor: Pierluigi Iacono

Copyright © 2019 Martin Stattin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Purpose. To assess the relationship between signs of activity in exudative neovascular age-related macular degeneration (nAMD) following anti-vascular endothelial growth factor (anti-VEGF) treatment and morphology of choroidal neovascularization (CNV) based on neovascular density as imaged using swept source-optical coherence tomography angiography (SS-OCTA) in a qualitative manner. Methods. A single-cohort retrospective data analysis from one tertiary eye care center. Seventy-seven eyes of 72 patients were included and their charts reviewed which had been started on intravitreal injections with anti-VEGF for nAMD at least one year prior to enrollment. Clinically active disease was evaluated by slit-lamp fundus examination and spectral domain-OCT B-scans. Morphological appearance in SS-OCTA was characterized based on 5 different criteria and subsequently divided into 3 groups: predominantly hyperdense, minimally hyperdense, and hypodense lesions. Results. Fifty-eight eyes (75%) were considered clinically active and 19 eyes (25%) clinically inactive. CNV was depicted in 71 eyes (92%) by SS-OCTA and separated accordingly into predominantly hyperdense (32%), minimally hyperdense (34%), and hypodense lesions (34%). A borderline significant difference in the probability of neovascular activity for predominantly hyperdense lesions compared to hypodense lesions was detected (). Conclusions. Hyperdense choroidal neovascularization based on qualitative assessment of flow density showed a significant relation to active disease. Inactivity could not be matched adequately. This study demonstrated the potential usefulness of SS-OCTA for guidance of treatment in age-related macular degeneration.