Relationship between Neovascular Density in Swept Source-Optical Coherence Tomography Angiography and Signs of Activity in Exudative Age-Related Macular Degeneration

Figure 1

Clinically active predominantly hyperdense choroidal neovascularization (CNV). (a) A sea-fan-like CNV formation with major feeder vessels (arrows) but mostly capillary branching (arrow-heads) and peripheral arcades or loops in (b) a nonperfused outer retina 6 × 6 mm swept source-optical coherence tomography angiography (SS-OCTA) segmentation image (DRI Triton, Topcon). (c) The same en-face layer revealed nonvascularized halos within the lesion and helped to localize its borders within (d) an underlying 6 × 6 mm choriocapillaris slab. (e) The mature vasculature was well visible in the corresponding infrared fundus photography (arrows). Smaller loops and branches (arrow-heads) could also be identified. (f) The spectral domain-OCT B-scan (Cirrus HD 4000, Zeiss) was acquired at the time of the last intravitreal injection 3 months prior to the SS-OCTA scan and demonstrated extensive intraretinal fluid (arrows).