Clinical and Ultrastructural Studies of Gelatinous Drop-Like Corneal Dystrophy (GDLD) of a Patient with TACSTD2 Gene Mutation

Figure 4

Electron micrograph of the GDLD cornea. (a) A whorl-like structure of the amyloid deposit containing very thin amyloid fibrils. (b) The electron-dense and electron-lucent amyloid fibril in the deposit. (c) Part of the stroma showing cross section of randomly distributed collagen fibrils; (d) part of the stroma showing randomly longitudinally running collagen fibrils with large proteoglycans; (e) part of the stroma showing very large proteoglycans (no staining of Ua and Pb); (f) part of the stroma showing a degenerated keratocyte containing large apoptotic nucleus. AM: amyloid deposits; CF: collagen fibrils; KR: keratocyte L: lamella; PG: proteoglycans; S: stroma.