Oral Hyaluronic Acid Supplementation for the Treatment of Dry Eye Disease: A Pilot Study

Table 1

Baseline demographics and clinical characteristics.

	Study group (topical + oral HA)	Control group (topical HA)	value
Number of patients	24	30
Age	48.6 ± 13.0	53.29 ± 10.8	0.073
Gender (% female)	75	76	0.755
Schirmer test (mm/5 min)	4.5 ± 1.0	4.9 ± 1.9	0.486
TBUT (sec)	3.3 ± 1.1	3.8 ± 1.5	0.104
CSF (Oxford score)	1.8 ± 1.0	1.5 ± 0.6	0.445
OSDI (score/100)	61.8 ± 16.2	62.5 ± 17.2	0.658

TBUT = tear break up time; CSF = corneal fluorescein staining; OSDI = ocular surface disease index. Data are expressed as mean ± standard deviation. value was tested by the Mann–Whitney U test.