Journal of Ophthalmology / 2019 / Article / Tab 1

Clinical Study

Oral Hyaluronic Acid Supplementation for the Treatment of Dry Eye Disease: A Pilot Study

Table 1

Baseline demographics and clinical characteristics.

Study group (topical + oral HA)Control group (topical HA) value

Number of patients2430
Age48.6 ± 13.053.29 ± 10.80.073
Gender (% female)75760.755
Schirmer test (mm/5 min)4.5 ± 1.04.9 ± 1.90.486
TBUT (sec)3.3 ± 1.13.8 ± 1.50.104
CSF (Oxford score)1.8 ± 1.01.5 ± 0.60.445
OSDI (score/100)61.8 ± 16.262.5 ± 17.20.658

TBUT = tear break up time; CSF = corneal fluorescein staining; OSDI = ocular surface disease index. Data are expressed as mean ± standard deviation. value was tested by the Mann–Whitney U test.

We are committed to sharing findings related to COVID-19 as quickly and safely as possible. Any author submitting a COVID-19 paper should notify us at to ensure their research is fast-tracked and made available on a preprint server as soon as possible. We will be providing unlimited waivers of publication charges for accepted articles related to COVID-19. Sign up here as a reviewer to help fast-track new submissions.