Outer Nuclear Layer as the Main Predictor to Anatomic Response to Half Dose Photodynamic Therapy in Chronic Central Serous Retinopathy
Table 4
Univariate and multivariate binomial regression to estimate the probability of anatomic response.
Variable
Univariate analysis Exp(B)
Univariate analysis p-value, 95% CI
Multivariate analysis, Exp(B)
Multivariate analysis p-value, 95% CI
Baseline best-corrected visual acuity
0.151
, 0.025 − 0.891
0.49
, 0.065 – 3.66
Time until diagnosis
1.005
, 0.976 – 1.035
X
Central macular thickness
1.001
, 0.997 – 1.005
X
Outer nuclear layer
1.04
, 1.01 – 1.07
1.04
, 1.007 – 1.071
External limiting membrane
0.244
, 0.059 – 1.008
X
Ellipsoid zone
0.267
, 0.078 − 0.915
1.27
, 0.268 – 6.029
Interdigitation zone
0.102
, 0.012 − 0.839
0.16
, 0.018 – 1.43
Choroidal thickness
1.005
, 0.996 – 1.014
X
Subretinal fluid
1.001
, 0.996 – 1.005
X
To estimate the probability of anatomic response of baseline variables, a univariate analysis of each variable to exclude possible confounders was performed initially, and subsequent multivariate analysis was performed. Only the outer nuclear layer was a significant predictor. , statistically significant; X, not included.
