Involvement of Inner Choroidal Layer in Choroidal Thinning during Regression of Multiple Evanescent White Dot Syndrome

Figure 2

Sequential changes in choroidal thickness of the mean whole, inner, and outer layers at the subfovea (a–c) with granular changes and the perifovea (d) with a white dot and/or a hypofluorescent spot observed on ICGA in patients with MEWDS, and correlations in choroidal thickness change from baseline to 3 months between the whole and inner layers (e) and between the whole and inner layers (f) at the subfovea in MEWDS eyes. (a) The mean whole choroidal thickness in MEWDS eyes (, black line) significantly decreased at 1 and 3 months, compared to baseline (Friedman test, ; Scheffe’s paired comparison test, and , respectively). By contrast, there was no significant change in the whole thickness of fellow eyes (, dotted line, Wilcoxon signed-rank test, ). (b) The mean inner choroidal layer thickness in MEWDS eyes significantly decreased at 1 and 3 months, compared to baseline (Friedman test, ; Scheffe’s paired comparison test, and , respectively). By contrast, there was no significant change in the inner layer thickness of fellow eyes (). (c) The mean choroidal outer layer thickness in MEWDS eyes tended to reduce with no statistically significant difference during the 3-month follow-up period (Friedman test, ). There was no significant change in the outer layer thickness of fellow eyes (). (d) Similarly, the mean whole and inner choroidal thicknesses () in MEWDS eyes significantly decreased at 1 and 3 months, compared to baseline (Friedman test, for each; Scheffe’s paired comparison test, for each and , , respectively). The outer choroidal layer thickness in MEWDS eyes tended to reduce (Friedman test, ). (e, f) There were significant positive correlations in baseline-to-3-month thickness changes between the whole and inner layers (Spearman’s rank correlation coefficient, R = 0.53, ) (d) and between the whole and outer layers (R = 0.91, ) (e).

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